Key result
Heart failure linked to ~31% higher sinoatrial node fibrosis vs non-failing hearts.
Why the study?
Heart failure can increase fibrosis in the human sinoatrial node, but nothing is known about the fibroblasts that maintain the inherently fibrotic sinoatrial node environment.
Observational (n=38)
Absolute Event Rate: 57.7% vs 44%
p-value: p=<0.0001
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Increased SAN fibrosis in HF may predispose to bradyarrhythmias; hypothesis-generating for matrix-targeted therapies.
Kalyanasundaram et al. (2021) conducted an observational in Heart Failure (n=38). Heart failure vs. Non-failing hearts was evaluated on Intranodal fibrotic content in the sinoatrial node pacemaker complex (p=<0.0001). Heart failure was associated with significantly higher intranodal fibrotic content in the sinoatrial node pacemaker complex compared to non-failing hearts (57.7% vs 44.0%, p<0.0001).
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