Why the study?
Can polymerase chain reaction identify Tropheryma whippelii as a causative organism in infective endocarditis?
Can polymerase chain reaction identify Tropheryma whippelii as a causative organism in infective endocarditis?
This report provides the first evidence of Tropheryma whippelii as a causative organism in infective endocarditis using PCR amplification from a native aortic valve.
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May aid targeted testing in culture-negative endocarditis; hypothesis-generating and should not yet change practice.
This report concerns a patient with cardiac manifestation of Whipple's disease. For the first time, the gene that encodes the 16s rRNA of Tropheryma whippelii was identified in a native aortic valve by means of a polymerase chain reaction technique. DNA amplification gives evidence of Tropheryma whippelii as a causative organism in infective endocarditis.
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Wendler et al. (1995) studied this question.
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