Key result
Plaque erosion drives coronary thrombosis in ~37% of young Indian patients with IHD.
Why the study?
Atherosclerotic CAD is of concern in young adults and has an increased prevalence in South Asian countries, particularly India, prompting evaluation of its autopsy pathology.
Population
95 autopsied patients aged ≤45 years with IHD out of 545 autopsied IHD cases
Design
10-year retrospective autopsy-based study at a large tertiary-care centre
Authors
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Should not yet change practice in young Indian IHD; leaves open ethnic differences in plaque erosion prevalence.
Observational (n=84)
No
This study highlights that in young Indian patients with fatal ischemic heart disease, plaque erosion with thrombosis is a major pathological mechanism, emphasizing the need for early screening and targeted prevention.
Vaideeswar et al. (2019) conducted an observational in Ischemic heart disease related to atherosclerotic coronary artery disease (n=84). Atherosclerotic coronary artery disease was evaluated on Pathology of atherosclerotic coronary artery disease (plaque morphology and complications). In young Indian patients with ischemic heart disease, the most common complication of atherosclerotic coronary artery disease was thrombosis produced by plaque erosion, observed in 36.9% of cases.
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