What does this research mean for the field?

TAP-independent and Brefeldin A-resistant MHC class I antigen processing is a distinct pathway that operates in parallel with classical processing, but is highly specific to certain cell types (T2 lineage) and viruses (Sendai virus). Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1995Scandinavian Journal of Immunology

Characterization of TAP‐Independent and Brefeldin A‐Resistant Presentation of Sendai Virus Antigen to CD8+ Cytotoxic T Lymphocytes

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Population

H-2Kb-transfected T2 cells (T2Kb cells) lacking TAP1/2 and LMP2/7 genes

Design

Preclinical

Authors

XZXianzheng ZhouShandong University TLT. LiuGeorgetown University LFLars FrankssonKarolinska University Hospital

Discussion

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Implication

Alternative MHC class I pathways operate in select cells; leaves open their role in antiviral immunity.

Structured PICO

Population

H-2Kb-transfected T2 cells (T2Kb cells) lacking TAP1/2 and LMP2/7 genes

Intervention

Sendai virus infection

Outcome

Antigen presentation to CD8+ cytotoxic T lymphocytes

Demonstrates that TAP1/2-independent and BFA-resistant class I processing is expressed in certain cell types in parallel with classical MHC class I processing, and Sendai virus selectively enters this pathway.

Cite This Study

Zhou et al. (1995) studied this question.

synapsesocial.com/papers/6a1de626871ff5209bef8405 https://doi.org/10.1111/j.1365-3083.1995.tb03627.x

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Characterization of TAP‐Independent and Brefeldin A‐Resistant Presentation of Sendai Virus Antigen to CD8+ Cytotoxic T Lymphocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of TAP‐Independent and Brefeldin A‐Resistant Presentation of Sendai Virus Antigen to CD8+ Cytotoxic T Lymphocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider