What question did this study set out to answer?

To analyze and accurately predict the 3' end formation of mRNAs in Caenorhabditis elegans.

June 21, 2004Nucleic Acids ResearchOpen Access

A probabilistic model of 3' end formation in Caenorhabditis elegans

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Computational analysis predicts 3' end formation in Caenorhabditis elegans, suggesting novel cleavage site dynamics.

To analyze and accurately predict the 3' end formation of mRNAs in Caenorhabditis elegans.
Conducted computational analysis by aligning cDNAs to genome sequences at poly(A) tracts.
Developed a generalized hidden Markov model to characterize sequence features in 3'-UTRs.
Predicted polyadenylation sites with a computer program based on the model.
Identified a significant number of true cleavage sites across various transcripts.
Predictions matched experimental observations for 3' ends featuring multiple AAUAAA motifs.
Compiled a comprehensive set of 6570 predicted polyadenylation sites supported by aligned transcripts.

Ashwin Hajarnavis (2004) studied this question.

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