What does this research mean for the field?

The M3 muscarinic acetylcholine receptor protects against myocardial ischemia injury by activating NF-κB to suppress miR-376b-5p, thereby preventing the downregulation of its target, BDNF. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

March 2, 2012PLoS ONEOpen Access

M3 Subtype of Muscarinic Acetylcholine Receptor Promotes Cardioprotection via the Suppression of miR-376b-5p

View Full Paper

Ask AI

Bookmark

Population

Rat model of myocardial ischemia and H9c2 cells

Design

Preclinical

Authors

ZPZhenyu PanGuangzhou Medical University YGYueping GuoHarbin Medical University HQHanping QiHarbin Medical University

Discussion

Member takes

Implication

Hypothesis-generating for M3-mAChR cardioprotection in ischemia; leaves open clinical translation pending human studies.

Structured PICO

Population

Rat model of myocardial ischemia and H9c2 cells

Intervention

M3-mAChR agonist choline

Outcome

Cardioprotection against myocardial ischemia injury (measured by cell viability, intracellular free Ca2+ concentration, reactive oxygen species, miR-376b-5p expression, BDNF, and NF-κB levels)surrogate

The M3-mAChR/NF-κB/miR-376b-5p/BDNF axis represents a novel mechanism for cardioprotection against myocardial ischemia injury.

Cite This Study

Pan et al. (2012) studied this question.

synapsesocial.com/papers/6a1dec8b79ea62caf6604486 https://doi.org/10.1371/journal.pone.0032571

View Full Paper

Ask AI

Bookmark

M3 Subtype of Muscarinic Acetylcholine Receptor Promotes Cardioprotection via the Suppression of miR-376b-5p

Discussion

Member takes

Implication

Structured PICO

Cite This Study

M3 Subtype of Muscarinic Acetylcholine Receptor Promotes Cardioprotection via the Suppression of miR-376b-5p

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider