Key result
M3-mAChR overexpression significantly reduced the arrhythmia score from 3.56 to 1.78 (p<0.01) and lowered mortality from 28% to 9% after myocardial ischemia-reperfusion injury in mice.
Population
562-L male M3 transgenic mice and their wild-type littermates, weighing approximately 25 g, subjected to…
Comparison
Cardiac-specific M3 muscarinic receptor… vs Wild-type littermates subjected to the same…
Design
Preclinical
Follow-up
2 hours
Authors
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May support M3-mAChR as antiarrhythmic target post-MI; leaves open human translation and trials.
Absolute Event Rate: 1.78% vs 3.56%
p-value: p=<0.01
Cardiac-specific overexpression of the M3 muscarinic receptor protects against ischemia-induced arrhythmias and mortality in mice, potentially by upregulating Kir2.1 and downregulating miR-1.
Liu et al. (2011) studied Myocardial ischemia-reperfusion injury (n=65). M3 muscarinic receptor (M3-mAChR) overexpression vs. Wild-type mice was evaluated on Arrhythmia score (p=<0.01). M3-mAChR overexpression significantly reduced the arrhythmia score from 3.56 to 1.78 (p<0.01) and lowered mortality from 28% to 9% after myocardial ischemia-reperfusion injury in mice.
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