Key result
M3-mAChR provides cardioprotection in cardiovascular disease through anti-arrhythmic, anti-hypertrophic, and anti-fibrotic effects.
Why the study?
Growing evidence links M3-mAChR to cardiovascular diseases with cardioprotective effects, warranting a summary of its expression patterns, functions, and mechanisms.
Design
Review
Authors
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M3-mAChR may emerge as therapeutic target in CVD; leaves open clinical translation pending prospective trials.
This review highlights the cardioprotective roles of the M3 muscarinic acetylcholine receptor and its potential as a therapeutic target in cardiovascular diseases.
Liu et al. (2024) conducted a review in Cardiovascular diseases. Muscarinic acetylcholine receptor M3 (M3-mAChR) was evaluated. The muscarinic acetylcholine receptor M3 (M3-mAChR) plays a cardioprotective role in cardiovascular diseases, including anti-arrhythmia, anti-hypertrophy, and anti-fibrosis effects.
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