Why the study?
Does in vitro anesthetic-induced preconditioning with isoflurane improve mitochondrial respiratory function and cell survival differently in mid-aged versus old-aged human atrial cardiomyocytes?
Population
Right atrial appendages from adult patients undergoing cardiac surgery, assigned to mid-aged and old-aged…
Comparison
In vitro anesthetic-induced preconditioning with… vs No APC / comparison between mid-aged and…
Design
Preclinical
Authors
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Isoflurane preconditioning may preserve mitochondrial function only in mid-aged myocytes; hypothesis-generating for age-dependent cardioprotection in humans.
Does in vitro anesthetic-induced preconditioning with isoflurane improve mitochondrial respiratory function and cell survival differently in mid-aged versus old-aged human atrial cardiomyocytes?
The cardioprotective effects of isoflurane preconditioning decline with age, likely due to altered mitochondrial function rather than changes in sarcKATP channel activity.
Mio et al. (2008) studied this question.
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