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Warrants no practice change yet with select antihypertensives; hypothesis-generating challenge to established benefits requiring prospective trials.
Although the beneficial effects of treating hypertension remain firmly established, concern has recently arisen that certain antihypertensive drugs may adversely modify cardiovascular risk factors. Equipotent blood pressure-lowering agents may also have differing effects on cardiac structure and function. Thus, established approaches to antihypertensive therapy are being questioned and revised or new approaches are being suggested.
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Joseph A. Franciosa (1984) studied this question.
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