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March 1, 1993The Journal of Clinical Pharmacology

Risk Factors Not Addressed in Antihypertensive Therapy Based Solely on Blood Pressure Control

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Why the study?

Do newer antihypertensive drugs with favorable metabolic and hemodynamic effects reduce coronary heart disease mortality in patients with hypertension compared to standard therapy?

Population

Patients with hypertension

Comparison

Newer antihypertensive drugs with favorable… vs Previously employed antihypertensive therapy…

Design

Review

Authors

JSJohn C. SombergHebrew Theological CollegeSESeymour EhrenpreisRosalind Franklin University of Medicine and ScienceGSGirish S. ShroffThe University of Texas MD Anderson Cancer Center

Discussion

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Implication

Theoretical support for newer antihypertensives does not justify practice change; leaves open whether they reduce CHD beyond BP lowering.

Structured PICO

Do newer antihypertensive drugs with favorable metabolic and hemodynamic effects reduce coronary heart disease mortality in patients with hypertension compared to standard therapy?

P
Population
Patients with hypertension
I
Intervention
Newer antihypertensive drugs with favorable metabolic and hemodynamic effects
C
Comparator
Previously employed antihypertensive therapy based solely on blood pressure control
O
Outcome
Mortality due to coronary artery disease

Newer antihypertensive agents may offer metabolic and hemodynamic benefits that could reduce coronary heart disease mortality beyond simple blood pressure control, though randomized trial data is currently lacking.

Limitations

  • Lack of randomized placebo-controlled studies demonstrating the proposed effect

Cite This Study

Somberg et al. (1993) studied this question.

synapsesocial.com/papers/6a6ff48426770c2b8de03f94https://doi.org/10.1002/j.1552-4604.1993.tb03957.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Five-Year Findings of the Hypertension Detection and Follow-up Program1979 · 1,259 citations
  2. 2Hypertension prevalence and the status of awareness, treatment, and control in the United States. Final report of the Subcommittee on Definition and Prevalence of the 1984 Joint National Committee.1985 · 269 citations
  3. 3Relative Heart Volume and Subsequent Mortality in Old People1989 · 1 citations
  4. 4Relation of Left Ventricular Mass and Geometry to Morbidity and Mortality in Uncomplicated Essential Hypertension1991 · 2,386 citations
  5. 5alpha 1-antagonists in the treatment of hypertension.1989 · 39 citations