Key result
Chitosan-coated alginate-PLGA microcapsules sustain metoprolol release and reduce initial burst release vs conventional microparticles.
Why the study?
Controversy remains regarding the degree of benefit achievable by treating milder hypertension and the comparative efficacy of different antihypertensive therapies in preventing complications and prolonging life.
Comparison
Various antihypertensive therapies including thiazide diuretics and beta-blockers
Design
Review of clinical trials and studies
Authors
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May support optimized metoprolol delivery in hypertension; leaves open clinical translation and outcomes in prospective trials.
Tifft et al. (1991) studied Hypertension. PLGA microcapsules encapsulating MET-loaded alginate nanoparticles vs. Conventional PLGA microparticles was evaluated on In vitro drug release profile. Encapsulation of metoprolol tartrate in chitosan-coated alginate nanoparticles within PLGA microcapsules provided sustained drug release with reduced initial burst release compared to conventional microparticles.
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