Key result
Antihypertensive therapy reduces hypertension complications and all-cause mortality, including in patients over 60.
Why the study?
Despite numerous deficiencies and questionable study selections in antihypertensive drug treatment trials and meta-analyses, treatment benefits from reducing hypertension have been demonstrated.
Antihypertensive therapy prevents stroke, HF, and mortality; confirms benefits across trials despite noted deficiencies.
Summary: Despite numerous deficiencies in some antihypertensive drug treatment trials, and some questionable selections of studies for inclusion in several meta‐analyses, undoubtedly such trials have shown treatment benefits from reducing hypertension. Complications that can be corrected or prevented include malignant hypertension, hypertensive heart failure, stroke and coronary artery morbidity. the all‐cause mortality has been lowered in several trials. the benefits have been seen in subjects aged over 60 years, in women and men, and in patients with isolated systolic hypertension. the benefits have been achieved using a wide range of drugs, not only with beta‐blockers or diuretics. Non‐pharmacological means of lowering blood pressure have not been evaluated in relation to morbidity.
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J. I. S. Robertson (1996) conducted a review in hypertension. Antihypertensive drug treatment was evaluated. Antihypertensive drug treatments reduce hypertension-related complications and all-cause mortality across various demographics, including subjects over 60 years.
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