Benefit and costs of anti-hypertensive treatment
Population
Patients with hypertension
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
May warrant greater use of 24-h BP monitoring; leaves open whether it improves outcomes over clinic measurements.
Key Points
- To review the clinical benefits, costs, and therapeutic strategies associated with anti-hypertensive treatment in mitigating cardiovascular risk and end-organ damage.
- Narrative evaluation of clinical evidence linking inadequately managed hypertension to major cardiovascular complications and healthcare costs.
- Comparison of clinical blood pressure monitoring versus 24-hour blood pressure profiles and variability in assessing end-organ damage risk.
- Anti-hypertensive treatment reduces cardiovascular-related risk, incidence of major cardiovascular complications, and overall mortality, with clinical trials frequently underestimating these benefits.
- Hypertension-related end-organ damage correlates more strongly with 24-hour average blood pressure and 24-hour variability than with isolated clinic-based blood pressure measurements.
- Inadequately treated hypertension leads to costly, disabling outcomes including stroke, coronary heart disease, congestive heart failure, and chronic renal failure.
Structured PICO
P
Population
Patients with hypertension
I
Intervention
Anti-hypertensive treatment
O
Outcome
Reduction of hypertension-related cardiovascular risk, major cardiovascular complications, and overall mortality
Anti-hypertensive treatment reduces cardiovascular complications, and 24-hour blood pressure monitoring may better predict and prevent end-organ damage than clinic measurements.
Cite This Study
Mancia et al. (1996) studied this question.