January 1, 2003Cerebrovascular Diseases
Clinical Trials: Evidence and Unanswered Questions – Hypertension
Why the study?
Does antihypertensive therapy prevent stroke in hypertensive and high-risk normotensive patients?
Population
Patients with mild, moderate, or severe hypertension, isolated systolic hypertension in the elderly, and…
Design
Review
Authors
Discussion
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Member takes
Implication
Affirms BP lowering for stroke prevention in high-risk patients; confirms consensus from prior trials while leaving optimal agents unresolved.
Structured PICO
Does antihypertensive therapy prevent stroke in hypertensive and high-risk normotensive patients?
P
Population
Patients with mild, moderate, or severe hypertension, isolated systolic hypertension in the elderly, and high-risk normotensive patients (previous stroke or established cardiovascular disease)
I
Intervention
Antihypertensive therapy (including diuretics, beta-blockers, calcium channel blockers, and ACE inhibitors)
O
Outcome
Primary and secondary prevention of strokehard clinical
This review highlights the established efficacy of blood pressure lowering for stroke prevention while noting ongoing uncertainty regarding the optimal choice of specific antihypertensive agents.
Cite This Study
David S. Celermajer (2003) studied this question.