Why the study?
Does antihypertensive treatment reduce cardiovascular risk in hypertensive subjects with additional risk factors?
Does antihypertensive treatment reduce cardiovascular risk in hypertensive subjects with additional risk factors?
This review highlights the established benefits of antihypertensive therapy in reducing cardiovascular risk while identifying ongoing trials, such as the Insight Study, that aim to address remaining clinical questions in high-risk populations.
BP lowering reduces CV risk in high-risk hypertensives; leaves open optimal targets and agents for ongoing trials like Insight.
Conclusive evidence from large-scale epidemiological studies has shown that hypertension is a major risk factor for cardiovascular disease. Large-scale intervention trials have indicated that, by reducing elevated blood pressure values with antihypertensive treatment, the risk can be decreased. Despite the large body of evidence on the protective effects of the blood pressure reduction, several questions concerning the benefit of antihypertensive treatment remain unanswered. This paper briefly reviews the information provided by clinical trials on antihypertensive treatment. It also critically examines the questions that have remained partially or totally unanswered and the trials that are currently addressing them. Focus is directed on the Insight Study which addresses the benefit of antihypertensive treatment in hypertensive subjects with additional cardiovascular risk factors.
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Mancia et al. (1996) studied this question.