Echocardiographic assessment of left ventricular hypertrophy and function in renal hypertensive dogs.
Why the study?
Does induction of perinephritic hypertension alter left ventricular hypertrophy and function in dogs?
Population
12 unanesthetized dogs
Comparison
Induction of perinephritic hypertension vs Sham-wrapping and contralateral nephrectomy
Design
Preclinical
Follow-up
6 months
Authors
Discussion
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Member takes
Implication
Does not inform clinical hypertension care; leaves open translation of compensated concentric hypertrophy beyond this canine model.
Structured PICO
Does induction of perinephritic hypertension alter left ventricular hypertrophy and function in dogs?
P
Population
12 unanesthetized dogs (8 induced with perinephritic hypertension, 4 sham-wrapping and contralateral nephrectomy controls)
I
Intervention
Induction of perinephritic hypertension
C
Comparator
Sham-wrapping and contralateral nephrectomy
O
Outcome
Left ventricular wall thickness and fractional shortening measured by M-mode echocardiographysurrogate
In a canine model of renal hypertension, early left ventricular hypertrophy is associated with increased cardiac performance that does not deteriorate as concentric hypertrophy becomes chronic over 6 months.
Cite This Study
RIOKA et al. (1982) studied this question.