Why the study?
Does cardiac resynchronization therapy improve functional outcomes in patients with congestive heart failure due to systolic dysfunction, wide QRS, and sinus rhythm?
Does cardiac resynchronization therapy improve functional outcomes in patients with congestive heart failure due to systolic dysfunction, wide QRS, and sinus rhythm?
Cardiac resynchronization therapy is a widely accepted and useful adjunct to pharmacologic therapy that provides functional improvement in appropriately selected heart failure patients.
Supports CRT for functional gains in systolic HF with wide QRS and sinus rhythm; confirms RCT consistency while leaving broader applications open.
Cardiac resynchronization represents a novel therapeutic strategy for the treatment of congestive heart failure due to systolic dysfunction. Since its modest beginnings in the 1990s, cardiac resynchronization therapy has gained widespread acceptance as a useful adjunct to pharmacologic therapy for congestive heart failure. Randomized trials have consistently shown functional improvement in patients with congestive heart failure due to systolic dysfunction, a wide QRS complex on electrocardiogram and sinus rhythm, that are treated with cardiac resynchronization therapy. This review article will address the rationale, mechanisms of action, limitations and appropriate selection of patients for cardiac resynchronization therapy.
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Wijetunga et al. (2005) studied this question.
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