Key result
Cardiac resynchronization therapy in patients with minimal heart failure symptoms is associated with left ventricular reverse remodeling and may prevent the progression of heart failure.
Why the study?
The effects of cardiac resynchronization therapy in patients with sinus rhythm, depressed LVEF, wide QRS, and minimal heart failure symptoms were uncertain.
Does cardiac resynchronization therapy induce left ventricular reverse remodeling and prevent the progression of heart failure in patients with minimally symptomatic heart failure?
Does cardiac resynchronization therapy induce left ventricular reverse remodeling and prevent the progression of heart failure in patients with minimally symptomatic heart failure?
Cardiac resynchronization therapy may offer benefits such as left ventricular reverse remodeling and prevention of disease progression in patients with minimally symptomatic heart failure.
May extend CRT to minimally symptomatic patients; leaves open outcome confirmation in randomized trials.
Cardiac resynchronization therapy improves mortality and heart failure symptoms in patients with sinus rhythm, depressed left ventricular ejection fraction, a wide QRS complex and moderate-to-severe heart failure symptoms. The results of recent trials suggest that in similar patients with minimal heart failure symptoms cardiac resynchronization therapy is associated with left ventricular reverse remodeling, and may prevent the progression of heart failure.
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Venkataraman et al. (2010) conducted a review in Minimally symptomatic heart failure. Cardiac resynchronization therapy was evaluated on Left ventricular reverse remodeling and progression of heart failure. Cardiac resynchronization therapy in patients with minimal heart failure symptoms is associated with left ventricular reverse remodeling and may prevent the progression of heart failure.
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