What does this research mean for the field?

Compound 48/80 inhibits the reversal of the sarcoplasmic reticulum Ca2+ pump by competing with orthophosphate for the enzyme's phosphorylation site, whereas ruthenium red inhibits fast Ca2+ efflux and ATP synthesis by competing with Ca2+ for the high-affinity binding site without affecting orthophosphate phosphorylation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1986Journal of Biological ChemistryOpen Access

Effect of compound 48/80 and ruthenium red on the Ca2+-ATPase of sarcoplasmic reticulum.

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Population

Sarcoplasmic reticulum Ca2+-ATPase of skeletal muscle

Design

Preclinical

Authors

EAElias W. AlvesUniversidade Federal do Rio de Janeiro LMLeopoldo de MeisUniversidade Federal do Rio de Janeiro

Discussion

Member takes

Implication

Distinct mechanisms of SR Ca2+-ATPase inhibitors in animals; extends basic research but leaves open human cardiac translation.

Structured PICO

Population

Sarcoplasmic reticulum Ca2+-ATPase of skeletal muscle

Intervention

Compound 48/80 and ruthenium red

Outcome

Effects on partial reactions of the catalytic cycle of the Ca2+-ATPase (ATPase activity, Ca2+ and Sr2+ uptake, Ca2+ efflux, ATP synthesis)surrogate

Compound 48/80 and ruthenium red inhibit different partial reactions of the sarcoplasmic reticulum Ca2+-ATPase catalytic cycle through distinct mechanisms.

Cite This Study

Alves et al. (1986) studied this question.

synapsesocial.com/papers/6a1e684960864841a668d856 https://doi.org/10.1016/s0021-9258(19)75966-3

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Effect of compound 48/80 and ruthenium red on the Ca2+-ATPase of sarcoplasmic reticulum.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of compound 48/80 and ruthenium red on the Ca2+-ATPase of sarcoplasmic reticulum.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider