July 1, 1984Journal of Biological ChemistryOpen Access

Energy interconversion in sarcoplasmic reticulum vesicles in the presence of Ca2+ and Sr2+ gradients.

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Population

Sarcoplasmic reticulum vesicles of rabbit skeletal muscle

Design

Preclinical

Authors

HGHorácio Guimarães-MottaUniversidade Federal do Rio de Janeiro MSM P Sande-LemosUniversidade Federal do Rio de Janeiro LMLeopoldo de MeisUniversidade Federal do Rio de Janeiro

Discussion

Member takes

Implication

Sr2+-impaired ATP synthesis in vesicles warrants caution extrapolating to cardiac SR; leaves open in vivo relevance for myocardial energetics.

Structured PICO

Population

Sarcoplasmic reticulum vesicles of rabbit skeletal muscle

Intervention

Ca2+ and Sr2+ gradients at varying Mg2+ concentrations

Outcome

ATP hydrolysis, ATP synthesis, and enzyme phosphorylationsurrogate

Sr2+ impairs ATP synthesis and ATP-Pi exchange in sarcoplasmic reticulum vesicles compared to Ca2+, highlighting differences in energy interconversion mechanisms.

Cite This Study

Guimarães-Motta et al. (1984) studied this question.

synapsesocial.com/papers/6a7c102fa540d02696c2bf17 https://doi.org/10.1016/s0021-9258(17)47208-5

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Implication

Sr2+-impaired ATP synthesis in vesicles warrants caution extrapolating to cardiac SR; leaves open in vivo relevance for myocardial energetics.

Energy interconversion in sarcoplasmic reticulum vesicles in the presence of Ca2+ and Sr2+ gradients.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Energy interconversion in sarcoplasmic reticulum vesicles in the presence of Ca2+ and Sr2+ gradients.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider