Why the study?
LBBB disrupts LV electrical activation and can potentially impair systolic function, leading to LBBB-induced cardiomyopathy.
Does the presence of left bundle branch block reduce cardiopulmonary exercise tolerance and left ventricular ejection fraction over 4 years in patients with initially preserved LVEF?
Does the presence of left bundle branch block reduce cardiopulmonary exercise tolerance and left ventricular ejection fraction over 4 years in patients with initially preserved LVEF?
In patients with initially preserved LVEF, the presence of LBBB is associated with reduced exercise tolerance and a progressive decline in LVEF over 4 years, suggesting early ventricular dysfunction.
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May warrant closer monitoring in LBBB with preserved LVEF; leaves open whether it drives progression or merits intervention trials.
Santos et al. (2024) studied this question.
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