Key result
Patients with left bundle branch block and heart failure had a significantly lower mean left ventricular ejection fraction compared to those without the conduction abnormality (32.6% vs. 41.9%).
Why the study?
Data regarding the impact of left bundle branch block on left ventricular systolic function in hospitalized heart failure patients remain limited.
Does the presence of left bundle branch block reduce left ventricular ejection fraction in adult patients hospitalized with heart failure?
Observational (n=120)
No
Does the presence of left bundle branch block reduce left ventricular ejection fraction in adult patients hospitalized with heart failure?
Absolute Event Rate: 32.6% vs 41.9%
p-value: p=< 0.001
The presence of left bundle branch block in heart failure patients is significantly associated with worsened left ventricular systolic function and increased ventricular dilatation, indicating advanced myocardial dysfunction.
Background: Left bundle branch block (LBBB) is frequently associated with structural heart disease and heart failure (HF) and is known to cause ventricular dyssynchrony, leading to impaired cardiac function.However, data regarding its impact on left ventricular systolic function in hospitalized HF patients remain limited.Methods: This prospective observational study was conducted among patients admitted with heart failure and electrocardiographic evidence of LBBB.Clinical characteristics, echocardiographic parameters, and outcomes were analyzed.Left ventricular ejection fraction (LVEF) was compared between patients with and without LBBB.Statistical analysis included Student's t-test, chi-square test, and Pearson correlation.Results: Patients with LBBB had significantly lower mean LVEF compared to those without LBBB (p < 0.001).LBBB was associated with higher prevalence of dilated cardiomyopathy, increased left ventricular dimensions, and higher rates of hospitalization.A significant negative correlation was observed between QRS duration and LVEF.Conclusion: LBBB is significantly associated with impaired left ventricular systolic function in heart failure patients.Its presence may indicate advanced myocardial dysfunction and poorer prognosis.Early recognition of LBBB may facilitate timely optimization of heart failure management.
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A 2026 study conducted an observational in Heart Failure (n=120). Left bundle branch block (LBBB) vs. Without LBBB was evaluated on Left ventricular ejection fraction (LVEF) (p=< 0.001). Patients with left bundle branch block and heart failure had a significantly lower mean left ventricular ejection fraction compared to those without the conduction abnormality (32.6% vs. 41.9%).
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