December 22, 2009European Journal of Heart Failure
Left Bundle Branch Block and Mortality in Patients with Acute Heart Failure Syndrome: A Substudy of the EFICA Cohort
Key result
Left bundle branch block was an independent predictor of 1-year mortality in 4-week survivors of a severe acute heart failure episode (HR 2.01; 95% CI 1.12-3.64; P=0.02).
Why the study?
Does the presence of LBBB increase short- and long-term mortality in patients admitted for a severe acute heart failure episode?
Population
403 patients with no history of NYHA class III and IV chronic heart failure, admitted for a severe acute…
Comparison
Presence of Left Bundle Branch Block (LBBB) vs Absence of Left Bundle Branch Block (no LBBB)
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
May warrant closer post-discharge monitoring in acute HF survivors; leaves open whether LBBB-targeted interventions improve outcomes.
Study Design
Type
Cohort (n=403)
Structured PICO
Does the presence of LBBB increase short- and long-term mortality in patients admitted for a severe acute heart failure episode?
P
Population
403 patients with no history of NYHA class III and IV chronic heart failure, admitted for a severe acute heart failure (AHF) episode (de novo or complicating mild CHF), enrolled in the prospective observational EFICA study.
I
Intervention
Presence of Left Bundle Branch Block (LBBB)
C
Comparator
Absence of Left Bundle Branch Block (no LBBB)
O
Outcome
4-week mortality and 1-year mortalityhard clinical
Main Result
Effect estimate: HR 2.01 (95% CI 1.12-3.64)
p-value: p=0.02
In patients surviving a severe episode of de novo or mild-on-chronic acute heart failure, the presence of LBBB independently predicts 1-year mortality.
Cite This Study
Huvelle et al. (2009) conducted a cohort in Acute Heart Failure Syndrome (n=403). Left bundle branch block (LBBB) vs. No LBBB was evaluated on 1-year mortality in 4-week survivors (HR 2.01, 95% CI 1.12-3.64, p=0.02). Left bundle branch block was an independent predictor of 1-year mortality in 4-week survivors of a severe acute heart failure episode (HR 2.01; 95% CI 1.12-3.64; P=0.02).