What question did this study set out to answer?

To evaluate the impact of left bundle branch block on long-term mortality in patients with symptomatic heart failure requiring hospitalization.

August 2, 2007European Heart JournalOpen Access

Influence of left bundle branch block on long-term mortality in a population with heart failure

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Why the study?

Does the presence of left bundle branch block (LBBB) independently increase long-term mortality in patients hospitalized with symptomatic heart failure?

Key Points

To evaluate the impact of left bundle branch block on long-term mortality in patients with symptomatic heart failure requiring hospitalization.
Prospective cohort study of 21,685 symptomatic heart failure cases from 1995-2003.
Long-term mortality analyzed using logistic regression adjusted for multiple confounders.
Mortality rates assessed at 1, 5, and 10 years for patients with and without left bundle branch block.
Patients with left bundle branch block had a 5-year mortality rate of 69.3% versus 61.3% without (OR, 1.21; 95% CI, 1.10-1.35; P < 0.001).
Including left ventricular ejection fraction in the analysis negated LBBB's independent impact on mortality (OR, 0.99; 95% CI, 0.62-1.56; P = 0.953).
LBBB occurred in 20% of heart failure admissions, correlating with a high prevalence of comorbid cardiac conditions.

Structured PICO

Does the presence of left bundle branch block (LBBB) independently increase long-term mortality in patients hospitalized with symptomatic heart failure?

Population

21,685 cases of symptomatic heart failure requiring hospitalization in the Register of Information and Knowledge about Swedish Heart Intensive care Admissions in 1995-2003

Intervention

Presence of left bundle branch block (LBBB)

Comparator

Absence of left bundle branch block (LBBB)

Outcome

Long-term mortality (1-, 5-, and 10-year)hard clinical

LBBB is associated with high mortality in hospitalized heart failure patients, but this appears driven by underlying cardiac comorbidities and myocardial dysfunction rather than LBBB itself.

Discussion

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Implication

LBBB lacks independent mortality effect in HF after LVEF adjustment; leaves open whether it modifies device therapy response in adjusted cohorts.

Cite This Study

Tabrizi et al. (2007) studied this question.

synapsesocial.com/papers/6a07f77e686e45fdbcfe0d58 https://doi.org/10.1093/eurheartj/ehm262

Topics

Heart failure hospitalization Heart failure HFrEF treatment

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Implication

LBBB lacks independent mortality effect in HF after LVEF adjustment; leaves open whether it modifies device therapy response in adjusted cohorts.

Influence of left bundle branch block on long-term mortality in a population with heart failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Influence of left bundle branch block on long-term mortality in a population with heart failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider