Key result
LBBB linked to ~538% higher acute arterial embolism risk in NVAF.
Why the study?
Atrial fibrillation commonly coexists with left bundle branch block, but whether LBBB independently predicts poor prognosis in non-valvular AF patients remains undetermined.
Does the presence of LBBB increase the risk of acute arterial embolism events and mortality in patients with non-valvular AF?
Population
5051 patients with non-valvular AF without apparent structural heart disease
Comparison
LBBB vs non-LBBB
Design
Retrospective propensity score-matched database cohort study
Follow-up
1-year
Authors
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LBBB was associated with higher AEE risk in non-valvular AF; hypothesis-generating and requires prospective validation before practice change.
Cohort (n=5,051)
No
Does the presence of LBBB increase the risk of acute arterial embolism events and mortality in patients with non-valvular AF?
Effect estimate: OR 6.38 (95% CI 1.10-36.93)
Absolute Event Rate: 13.8% vs 3.8%
p-value: p=0.04
In patients with non-valvular atrial fibrillation, the presence of LBBB is an independent risk factor for acute arterial embolism events and in-hospital cardiac death.
Zhao et al. (2024) conducted a cohort in Non-valvular atrial fibrillation (n=5,051). Left bundle branch block (LBBB) vs. Non-LBBB was evaluated on Acute arterial embolism events (AEE) (OR 6.38, 95% CI 1.10-36.93, p=0.04). In patients with non-valvular atrial fibrillation, left bundle branch block independently increased the risk of acute arterial embolism events (OR 6.38) compared to patients without LBBB.
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