Why the study?
It remained unclear how low on-treatment diastolic blood pressure influenced the risk of stroke events during systolic blood pressure lowering.
Does low on-treatment diastolic blood pressure increase the risk of first stroke in a high-risk hypertensive population?
Population
8944 SPRINT participants
Comparison
On-treatment DBP <70 mm Hg vs DBP ≥70 mm Hg
Design
Secondary analysis of a randomized clinical trial
Authors
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Low on-treatment DBP was not independently linked to stroke; leaves open whether intensive SBP lowering is safe in high-risk hypertension.
Does low on-treatment diastolic blood pressure increase the risk of first stroke in a high-risk hypertensive population?
Low on-treatment diastolic blood pressure is not independently associated with an increased risk of first stroke in high-risk hypertensive patients, suggesting that intensive systolic blood pressure lowering does not cause harm via low diastolic pressures.
Sobieraj et al. (2019) studied this question.
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