What question did this study set out to answer?

Examine the effects of incremental doses of procainamide on ventricular refractoriness and the induction of ventricular tachycardia.

December 1, 1986CirculationOpen Access

Effects of incremental doses of procainamide on ventricular refractoriness, intraventricular conduction, and induction of ventricular tachycardia.

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Authors

FMF MoradyElectrophysiology LDLorenzo A. DiCarloElectrophysiology MBMichael de BuitleirUniversity of Wisconsin–Madison

Discussion

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Implication

Randomized trial evaluates procainamide's impact on ventricular conduction and tachycardia induction in patients, suggesting dose considerations for therapy.

Key Points

Examine the effects of incremental doses of procainamide on ventricular refractoriness and the induction of ventricular tachycardia.
Included 31 patients with history of ventricular tachycardia
Incremental doses of procainamide (7.5 to 30 mg/kg) administered
QRS duration monitored during ventricular pacing to assess conduction changes.
7.5 mg/kg dose suppressed ventricular tachycardia induction in 8 of 31 patients
Higher doses suppressed tachycardia in 2 additional patients
Sustained tachycardia was inducible again in some patients after higher doses.

Cite This Study

Morady et al. (1986) studied this question.

synapsesocial.com/papers/6a1e70d4e6eabd489e68a93b https://doi.org/10.1161/01.cir.74.6.1355

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Implication

Randomized trial evaluates procainamide's impact on ventricular conduction and tachycardia induction in patients, suggesting dose considerations for therapy.

Effects of incremental doses of procainamide on ventricular refractoriness, intraventricular conduction, and induction of ventricular tachycardia.

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of incremental doses of procainamide on ventricular refractoriness, intraventricular conduction, and induction of ventricular tachycardia.

Discussion

Member takes

Implication

Key Points

Cite This Study

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