Why the study?
Does intravenous procainamide alter the inducibility of ventricular tachyarrhythmias in dogs with experimental myocardial infarction?
Population
35 dogs with experimental myocardial infarction and 9 normal dogs
Comparison
Intravenous procainamide (15 mg/kg) vs Baseline (before procainamide administration)
Design
Preclinical
Authors
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Procainamide may promote sustained VT over VF in postinfarct models; leaves open relevance to human arrhythmia management.
Does intravenous procainamide alter the inducibility of ventricular tachyarrhythmias in dogs with experimental myocardial infarction?
In a canine model of myocardial infarction, procainamide exhibited a proarrhythmic effect by converting inducible ventricular fibrillation to sustained ventricular tachycardia, suggesting caution for its use in post-MI patients.
Hunt et al. (1990) studied this question.
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