Why the study?
Does a positive exercise electrocardiogram predict coronary events differently in men and women with atypical chest pain?
Does a positive exercise electrocardiogram predict coronary events differently in men and women with atypical chest pain?
Exercise electrocardiography has a significantly poorer predictive value for hard coronary events in women compared to men presenting with atypical chest pain.
Positive exercise ECGs associate with lower coronary event rates in women than men; hypothesis-generating for sex-specific thresholds in atypical chest pain.
In 1,455 subjects (947 men and 508 women) who underwent a bicycle ergometer stress test for evaluation of atypical chest pain, the incidence of coronary events (definite myocardial infarction or sudden death) was assessed by the life table method. The follow-up period ranged from 3 to 7 years (mean 5.2 years). In men with positive exercise test (ischemic ST depression ≧ 1 mm), the 5-year incidence of coronary events was 18.3%, compared with 1.9% in negative responders. In women with positive response, the 5-year incidence of coronary events was 4.6%; in negative responders, it was 0.3%. The poor predictive value of ischemic ST responses to exercise in women is emphasized.
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Manca et al. (2008) studied this question.
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