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September 2, 2026Journal of the American College of CardiologyOpen Access

Prognostic value of exercise echocardiographyin 5,798 patients: is there a gender difference?

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Key result

Male gender is linked to ~71% more cardiac events, despite comparable exercise echo prognostic value.

  • P=0.001
  • n=5,798

Why the study?

Limited information exists regarding gender differences in the prognostic value of exercise echocardiography.

Does the prognostic value of exercise echocardiography differ between men and women with known or suspected coronary artery disease?

Population

5,798 consecutive patients undergoing exercise echocardiography for known or suspected CAD

Comparison

Men vs women

Design

Observational cohort study

Follow-up

3.2 +/- 1.7 years

Authors

AAAdelaide M. Arruda‐OlsonWinnMedEJEldyn M JuracanMayo ClinicDMDouglas W. MahoneyHeart Failure & Transplant

Discussion

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Implication

Exercise echocardiography provides comparable incremental prognostic value for predicting cardiac events in both men and women with known or suspected coronary artery disease.

Key Points

  • To evaluate the prognostic capacity of exercise echocardiography in predicting cardiovascular outcomes and determine if performance varies by patient gender.
  • Assessed clinical and exercise echocardiographic data from a cohort of 5,798 patients.
  • Tracked cardiovascular events and stratified prognostic outcomes according to patient sex.
  • Exercise echocardiography provides meaningful prognostic information for long-term cardiovascular risk stratification.
  • Outcomes clarify whether diagnostic and prognostic accuracy differs significantly between men and women undergoing stress imaging.

Study Design

Type

Cohort (n=5,798)

Structured PICO

Does the prognostic value of exercise echocardiography differ between men and women with known or suspected coronary artery disease?

P
Population
5,798 consecutive patients (42.7% female, mean age 62 years) with known or suspected coronary artery disease undergoing exercise echocardiography, followed for a mean of 3.2 years.
E
Exposure
Exercise echocardiography
C
Comparator
Comparison between men and women
O
Outcome
Cardiac events (cardiac death and nonfatal myocardial infarction)hard clinical

Main Result

Absolute Event Rate: 5.3% vs 3.1%

p-value: p=0.001

Exercise echocardiography provides comparable incremental prognostic value for predicting cardiac events in both men and women with known or suspected coronary artery disease.

Cite This Study

Arruda‐Olson et al. (2002) conducted a cohort in known or suspected coronary artery disease (n=5,798). Male gender vs. Female gender was evaluated on Cardiac events, including cardiac death and nonfatal myocardial infarction (p=0.001). Male gender was associated with a higher rate of cardiac events than female gender (5.3% vs 3.1%, p=0.001), but the incremental prognostic value of exercise echocardiography was comparable.

synapsesocial.com/papers/6a97e9f30e613c950205a1f2https://doi.org/10.1016/s0735-1097(01)01801-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differences in electrocardiographic response to exercise of women and men: a non-Bayesian factor.1979 · 168 citations
  2. 2ACC/AHA 2002 Guideline Update for Exercise Testing: Summary Article2002 · 2,612 citations
  3. 3Sex and Test Verification Bias1997 · 194 citations
  4. 4Role of Dobutamine Stress Echocardiography in Predicting Outcome in 860 Patients With Known or Suspected Coronary Artery Disease1998 · 223 citations
  5. 5Exercise Stress Testing1979 · 590 citations