Population
40 patients undergoing elective aortic valve replacement, including 20 with dominant aortic stenosis and 20…
Design
Case-control
Authors
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May link local coagulation to aortic stenosis pathogenesis; hypothesis-generating, should not yet change practice.
Tissue factor expression and macrophage infiltration are significantly increased in the aortic valves of patients with aortic stenosis compared to those with aortic insufficiency, suggesting a role for local coagulation in AS pathogenesis.
Natorska et al. (2009) studied this question.
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