What does this research mean for the field?

A combination of electrochemiluminescent (ECL) serology assays using four RSV antigens provides 95% diagnostic sensitivity and 100% specificity for detecting recent RSV infection in the elderly, outperforming commercially available ELISA and cell-based microneutralization assays. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 12, 2016PLoS ONEOpen Access

Development of Electrochemiluminescent Serology Assays to Measure the Humoral Response to Antigens of Respiratory Syncytial Virus

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Why the study?

Do electrochemiluminescent serology assays accurately detect recent RSV infection in elderly subjects compared to standard diagnostic methods?

Population

89 elderly subjects, including 59 RSV-positive and 30 RSV-negative individuals providing acute and…

Comparison

Four electrochemiluminescent serology assays… vs 'Gold standard' diagnosis, commercially…

Authors

SMSarah V. MaifeldSerimmune (United States)RBRo BodreySerimmune (United States)HMHoyin MokVanderbilt University

Discussion

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Implication

May enhance RSV serodiagnosis in elderly; leaves open prospective validation before clinical adoption.

Structured PICO

Do electrochemiluminescent serology assays accurately detect recent RSV infection in elderly subjects compared to standard diagnostic methods?

Population

89 elderly subjects (≥65 years old), including 59 RSV-positive and 30 RSV-negative individuals providing acute and convalescent serum samples.

Intervention

Four electrochemiluminescent (ECL) serology assays using RSV antigens F, N, Ga, and Gb.

Comparator

'Gold standard' diagnosis, commercially available diagnostic ELISA, and cell-based microneutralization assay.

Outcome

Diagnostic sensitivity and specificity for detecting recent RSV infection.surrogate

ECL-based serology assays provide a highly sensitive and specific diagnostic approach for detecting recent RSV infection in the elderly.

Cite This Study

Maifeld et al. (2016) studied this question.

synapsesocial.com/papers/6a1e86b57f6e8bbb23690a7f https://doi.org/10.1371/journal.pone.0153019

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Development of Electrochemiluminescent Serology Assays to Measure the Humoral Response to Antigens of Respiratory Syncytial Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Development of Electrochemiluminescent Serology Assays to Measure the Humoral Response to Antigens of Respiratory Syncytial Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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