What does this research mean for the field?

Myopalladin is a novel sarcomeric protein that maintains sarcomeric integrity by tethering nebulin/nebulette to alpha-actinin in Z-lines and linking structural regulation to muscle gene expression via its interaction with CARP. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

April 16, 2001The Journal of Cell BiologyOpen Access

Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies

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Population

Live cardiac myocytes and vertebrate striated muscle

Design

Preclinical

Authors

MBMarie‐Louise BangIRCCS Humanitas Research Hospital RMRyan E. MudryUniversity of Arizona AMAbigail McElhinnyCox & Company (United States)

Discussion

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Implication

Myopalladin-CARP disruption of sarcomeres is hypothesis-generating; leaves open relevance to human cardiomyopathy pending further study.

Structured PICO

Population

Live cardiac myocytes and vertebrate striated muscle

Intervention

Overexpression of myopalladin's NH(2)-terminal CARP-binding region

Outcome

Disruption of sarcomeric componentssurrogate

Identification of myopalladin as a novel sarcomeric protein that interacts with CARP and is essential for maintaining sarcomeric integrity in cardiac myocytes.

Cite This Study

Bang et al. (2001) studied this question.

synapsesocial.com/papers/6a1e87f57f6e8bbb23690c6a https://doi.org/10.1083/jcb.153.2.413

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Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider