What question did this study set out to answer?

Update the CASTp platform to integrate functional residue annotations and disease-related variants with geometric measurements of protein surface cavities and voids.

July 1, 2006Nucleic Acids ResearchOpen Access

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues

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Update the CASTp platform to integrate functional residue annotations and disease-related variants with geometric measurements of protein surface cavities and voids.
Extracted functional annotations and disease-causing variant single nucleotide polymorphisms (SNPs) from Swiss-Prot, OMIM, and the Protein Data Bank (PDB).
Applied a semi-global pair-wise sequence alignment method to map sequence data from Swiss-Prot and OMIM directly to corresponding PDB structures.
Mapped annotated residues onto computed topographical surface pockets and interior voids across 3D protein structures.
Established an updated CASTp web resource that simultaneously computes the geometric dimensions of surface pockets and visualizes functional annotations.
Successfully correlated disease-causing genetic mutations from OMIM with specific structural cavities and functional regions on 3D protein surfaces.

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Implication

Computational tool update integrates functional residue annotations into 3D protein surface topography, facilitating the structural analysis of disease-causing mutations.

Cite This Study

Dundas et al. (2006) studied this question.

synapsesocial.com/papers/6a1e8a9d8a8a691223560485 https://doi.org/10.1093/nar/gkl282

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Implication

Computational tool update integrates functional residue annotations into 3D protein surface topography, facilitating the structural analysis of disease-causing mutations.

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues

Key Points

Discussion

Implication

Cite This Study

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues

Key Points

Discussion

Implication

Cite This Study

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