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Design
Review
May inform HF management via hemodynamic concepts; leaves open integration with contemporary trial data.
The performance of the heart is regulated by the level of myocardial contractility and the cardiac preload and afterload. These factors, previously of interest primarily to basic scientists, are now clinically important for an understanding of both cardiac function and therapeutics. In this brief review, the essence of these concepts is summarized and related to the treatment of cardiac failure.
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Robert Little (1982) studied this question.
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