Key result
Afterload mismatch correction proves crucial in HF while the Frank-Starling mechanism plays little sarcomeric role.
In heart failure, afterload reduction is of major importance for improving cardiac output, provided venous return is maintained, while the Frank-Starling mechanism plays little role at the sarcomere level.
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May explain stroke volume maintenance via geometric enlargement; leaves open optimal afterload reduction timing in chronic HF.
John Ross (1983) conducted a review in Heart failure. Nitroprusside and inotropic agents was evaluated. Afterload mismatch and its correction are of major importance in heart failure, whereas the Frank-Starling mechanism plays little role at the sarcomere level.
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