Why the study?
Does enhanced preload increase force development in explanted human failing hearts with end-stage heart failure?
Does enhanced preload increase force development in explanted human failing hearts with end-stage heart failure?
The Frank-Starling mechanism is preserved in terminally failing human hearts regardless of the underlying etiology or severity of cardiac impairment.
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Preserved Frank-Starling response in explanted end-stage HF hearts; leaves open in vivo relevance and therapeutic translation.
Weil et al. (1998) studied this question.
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