Why the study?
Does flurbiprofen reduce alveolar bone resorption in beagles with chronic destructive periodontal disease?
Does flurbiprofen reduce alveolar bone resorption in beagles with chronic destructive periodontal disease?
Flurbiprofen significantly decreases alveolar bone resorption in a beagle model of periodontitis, suggesting a potential role in managing bone resorption diseases.
No immediate clinical implications for human periodontitis; leaves open translation of NSAID effects on alveolar bone loss.
The nonsteroidal anti-inflammatory drug, flurbiprofen, a potent cyclooxygenase inhibitor, significantly decreases the resorption of alveolar bone in naturally occurring chronic destructive periodontal disease in beagles. This observation indicates that arachidonic acid metabolites are important in the alveolar bone loss of periodontitis and suggests a use for flurbiprofen in the management of bone resorption disease.
No takes yet. Share an insight, caveat, or question.
Williams et al. (1985) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: