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The effects of left stellate ganglion stimulation on haemodynamics and coronary blood flow were studied in dogs, and compared with hypoxia produced by arterial anoxia. Both left stellate stimulation and hypoxia resulted in an increase in coronary blood flow and myocardial oxygen consumption, but the increment in coronary blood flow was much more pronounced during hypoxia. Coronary resistance was significantly reduced during hypoxia but not altered during left stellate stimulation. This suggests an inadequate coronary vasodilator response during left stellate stimulation, probably secondary to a vasoconstrictor effect of the sympathetic nerves. This vasoconstrictor effect interferes with maximum vasodilatory response to hypoxia that is induced by sympathetic stimulation.
Obeid et al. (Fri,) studied this question.