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June 30, 2017Diabetes

The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor

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To determine whether the antagonist GIP(3–30)NH2 blocks the physiological effects of glucose-dependent insulinotropic polypeptide (GIP) on glucose metabolism, abdominal adipose tissue blood flow, and lipid uptake in humans.
Studied 8 lean individuals across three distinct occasions using hyperglycemic-hyperinsulinemic clamps.
Administered concomitant infusions of GIP alone, GIP(3–30)NH2 alone, or a combination of GIP and GIP(3–30)NH2.
Measured arteriovenous concentrations of metabolites and subcutaneous abdominal adipose tissue blood flow (ATBF).
Infusion of GIP(3–30)NH2 alone or combined with GIP resulted in lower plasma insulin levels and decreased glucose infusion rates needed to maintain the clamp compared to GIP alone.
Adipose tissue blood flow remained unchanged with the antagonist alone and increased only slightly when combined with GIP, whereas GIP alone stimulated a fivefold increase in blood flow.
Antagonist infusion alone and with GIP reduced adipose tissue triacylglyceride and glucose uptake, while increasing the free fatty acid-to-glycerol ratio.

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Implication

Clinical trial demonstrates that GIP receptor antagonism blunts insulin secretion, adipose blood flow, and lipid uptake in lean humans, highlighting GIP's multi-tissue metabolic role.

Cite This Study

Asmar et al. (2017) studied this question.

synapsesocial.com/papers/6a1ea325989adebfe89a62cf https://doi.org/10.2337/db17-0480

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Implication

Clinical trial demonstrates that GIP receptor antagonism blunts insulin secretion, adipose blood flow, and lipid uptake in lean humans, highlighting GIP's multi-tissue metabolic role.

The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor

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Discussion

Implication

Cite This Study

The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor

Key Points

Discussion

Implication

Cite This Study

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