What question did this study set out to answer?

Identify and evaluate all published randomized clinical trials investigating pharmacological interventions for core symptoms in adults with autism spectrum disorder.

April 7, 2023Open Access

Systematic review of randomized clinical trials testing a pharmacological treatment in adults with autism spectrum disorder

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Authors

AMAlicia Pérez MiguelUniversitat de Miguel Hernández d'Elx MMMa Luisa Sánchez de Ocaña MorenoUniversitat de Miguel Hernández d'Elx APAna M. PeiróUniversitat de Miguel Hernández d'Elx

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Implication

Systematic review reveals sparse evidence and high heterogeneity among drug trials in adults with autism spectrum disorder, highlighting the urgent need for standardized large-scale studies.

Key Points

Identify and evaluate all published randomized clinical trials investigating pharmacological interventions for core symptoms in adults with autism spectrum disorder.
Searched Medline and Scopus databases to retrieve clinical trials investigating drug therapies in adults with autism spectrum disorder.
Assessed methodological quality using Consolidated Standards of Reporting Trials (CONSORT) guidelines on a 0% to 100% scale.
Included 17 clinical trials out of 86 retrieved (20%), with an average CONSORT quality score of 70%.
Identified low sample sizes across trials, ranging from 30 participants in single-center trials to 115 in multicenter studies, with a mean participant age of 27 years.
Evaluated medications focused on social interaction (propranolol, oxytocin), cognition (cannabidiol), behavior (naltrexone, vasopressin V1a antagonists, dextromethorphan, quinidine, agomelatine, citalopram), and emotion recognition.

Cite This Study

Miguel et al. (2023) studied this question.

synapsesocial.com/papers/6a1ea80e00756c160baf1f8e https://doi.org/10.21203/rs.3.rs-2759981/v1

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Implication

Systematic review reveals sparse evidence and high heterogeneity among drug trials in adults with autism spectrum disorder, highlighting the urgent need for standardized large-scale studies.

Systematic review of randomized clinical trials testing a pharmacological treatment in adults with autism spectrum disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

Systematic review of randomized clinical trials testing a pharmacological treatment in adults with autism spectrum disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

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