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October 12, 2025Journal of Autism and Developmental DisordersOpen Access

Efficacy of Antioxidant-Based Pharmacological Therapies in Autism Spectrum Disorder: A Systematic Review

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Authors

SRSofía Ramírez-GuerreroAPAlejandro Puerta-MurciaNMNatalia Martinez-Benavides

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Overview

Systematic review evaluates antioxidant-based pharmacological therapies for autism symptoms, indicating mixed efficacy.

Key Points

  • Antioxidant pharmacological therapy shows varying effectiveness in addressing core symptoms of autism spectrum disorder.
  • Notable improvements were reported with treatments like sulforaphane and N-Acetylcysteine in behavioral symptoms.
  • A systematic review assessed 20 studies, utilizing the Cochrane Risk-of-Bias tool for evaluation.
  • Despite some positive findings, caution is warranted in recommending antioxidants as standalone treatment for autism.

Cite This Study

Ramírez-Guerrero et al. (2025) studied this question.

synapsesocial.com/papers/68ebe3d6becc64ad52fdad8ahttps://doi.org/10.1007/s10803-025-07059-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitochondrial dysfunction and oxidative stress in autism spectrum disorder: pharmacological insights into natural antioxidants2026
  2. 2Dietary interventions for autism spectrum disorder: An updated systematic review of human studies2022 · 32 citations
  3. 3Effects of nutritional supplementation on social impairment and behavioral dysregulation in autism spectrum disorder: a network meta-analysis2026
  4. 4Systematic Review: The Effect of Omega-3 Consumption on Individuals with Autism Spectrum Disorder2025
  5. 5Systematic review of randomized clinical trials testing a pharmacological treatment in adults with autism spectrum disorder2023