Key result
Plasma vaspin concentration correlates with the severity of coronary artery disease and may inhibit atherogenesis and contribute to plaque stabilization.
Why the study?
Although adipokines are elevated in atherosclerotic lesions, their exact role in the atherosclerotic process and the relationship between vaspin levels and coronary artery disease remain to be elucidated.
Vaspin is a promising biomarker and potential therapeutic target that may protect against atherosclerosis and stabilize coronary plaques.
Vaspin measurement should not yet inform CAD management; hypothesis-generating for biomarker and therapeutic roles.
The relationship between serum vaspin levels and metabolic or coronary artery disease is currently of interest for researchers. Although adipokine concentrations have been shown to be increased significantly in atherosclerotic lesions, the role adipokines in the atherosclerotic process remains to be elucidated. Vaspin is a new biological marker associated with obesity and impaired insulin sensitivity. Plasma vaspin concentration has been shown to correlate with the severity of coronary artery disease. Vascular inflammation triggered by vaspin inhibits atherogenesis by suppressing macrophage foam cell formation and vascular smooth muscle cell migration and proliferation. Vaspin also contributes to plaque stabilization by increasing collagen content and reducing the intraplaque macrophage to vascular smooth muscle cell ratio. The therapeutic goal concerning vaspin is to fight atherosclerosis and related diseases, as well as to maintain vascular health.
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Aşkın et al. (2020) conducted a review in Coronary Artery Disease. Vaspin levels was evaluated. Plasma vaspin concentration correlates with the severity of coronary artery disease and may inhibit atherogenesis and contribute to plaque stabilization.
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