Why the study?
Does methylatropine or atenolol reduce cardiovascular responses to novelty stress in conscious, freely-moving female spontaneously hypertensive rats?
Does methylatropine or atenolol reduce cardiovascular responses to novelty stress in conscious, freely-moving female spontaneously hypertensive rats?
Cardiac responses to novelty stress in spontaneously hypertensive rats are predominantly driven by sympathetic activation with a minor component of vagal withdrawal.
Supports sympathetic predominance in novelty stress tachycardia in SHR; hypothesis-generating for autonomic mechanisms, no clinical translation yet.
Cardiac hemodynamic mechanisms involved in cardiovascular responses to stress were studied in conscious, freely-moving female spontaneously hypertensive rats exposed for 15 min to an open-field. When pretreated with saline, the rats displayed a rapid rise in blood pressure, heart rate, aortic dP/dt and locomotor activity. In rats pretreated with 0.5 mg/kg of methylatropine, the tachycardia was slightly, but significantly reduced. In rats pretreated with 1 mg/kg of atenolol, the tachycardis and rise in dP/dt were markedly reduced. These data suggest that the cardiac responses to stress include predominantly cardiac sympathetic activation and a minor component of vagal withdrawal.
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Maarten van den Buuse (2002) studied this question.
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