Why the study?
The FDA black-box warning regarding increased suicidality in individuals under 25 years old taking antidepressants has been controversial, prompting investigation into SSRI or SNRI use and suicide-related readmissions in newly diagnosed depressive disorder.
Does age or sex affect the risk of readmission due to suicide-related events within 90 days in patients newly diagnosed with depressive disorders started on SSRIs or SNRIs?
Does age or sex affect the risk of readmission due to suicide-related events within 90 days in patients newly diagnosed with depressive disorders started on SSRIs or SNRIs?
Younger age and male sex are associated with an increased risk of 90-day hospital readmission due to suicide-related events following the initiation of SSRIs or SNRIs for newly diagnosed depressive disorders.
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May warrant closer surveillance in younger men; hypothesis-generating for targeted prevention strategies in observational data.
Colon et al. (2022) studied this question.
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