Key result
Intramuscular influenza vaccination in patients receiving long-term warfarin therapy caused no significant change in prothrombin time and no local bleeding complications.
Why the study?
Does intramuscular influenza immunization affect prothrombin time or cause local bleeding complications in patients receiving long-term warfarin therapy?
Population
41 adult patients receiving long-term warfarin sodium therapy
Design
Cohort, Patients and study nurses were blinded to all prior measurements
Follow-up
14 days
Authors
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May support IM influenza vaccination safety in warfarin patients; leaves open need for randomized confirmation.
Does intramuscular influenza immunization affect prothrombin time or cause local bleeding complications in patients receiving long-term warfarin therapy?
Intramuscular influenza vaccination is safe and does not significantly alter prothrombin time in patients on long-term warfarin therapy.
Guna Raj (1995) studied Long-term warfarin anticoagulation therapy (n=41). Intramuscular influenza vaccine vs. Baseline (self-controlled) was evaluated on Change in prothrombin time and arm circumference from baseline to days 3, 7, and 14. Intramuscular influenza vaccination in patients receiving long-term warfarin therapy caused no significant change in prothrombin time and no local bleeding complications.
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