Key result
Exposure to 5 microM ryanodine reduced developed forces to 10-15% of maximum twitch force and increased the rate of Ca2+ release during the twitch in ferret papillary muscles.
In ferret papillary muscles, ryanodine causes a negative inotropic effect by increasing both the systolic sarcoplasmic reticulum Ca2+ release rate and diastolic Ca2+ leakiness.
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Extends mechanistic insight into ryanodine effects on SR Ca2+ handling in animal models; leaves open translation to human myocardium.
Urthaler et al. (1989) studied this question. Ryanodine vs. Baseline (before ryanodine) was evaluated on Contractile performance (developed forces). Exposure to 5 microM ryanodine reduced developed forces to 10-15% of maximum twitch force and increased the rate of Ca2+ release during the twitch in ferret papillary muscles.
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