September 1, 1987AJP Cell Physiology
Effects of rest duration and ryanodine on changes of extracellular [Ca] in cardiac muscle from rabbits
Key result
Ryanodine enhanced cumulative depletions of extracellular calcium after short rest intervals and increased the rate of calcium loss from rabbit ventricular muscle cells upon cessation of stimulation.
Population
Rabbit ventricular muscle
Comparison
Ryanodine and varying rest intervals vs Untreated muscles / baseline conditions
Design
Preclinical
Authors
Discussion
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Implication
No immediate clinical implications from rabbit data; leaves open ryanodine effects on human ventricular calcium handling.
Structured PICO
P
Population
Rabbit ventricular muscle
I
Intervention
Ryanodine (1 to 10 microM) and varying rest intervals (10 s to 10 min)
C
Comparator
Untreated muscles / baseline conditions
O
Outcome
Cumulative depletions of extracellular Casurrogate
Ryanodine enhances the loss of cellular calcium on cessation of stimulation in rabbit ventricular muscle, suggesting an effect on sarcoplasmic reticulum calcium handling.
Cite This Study
MacLeod et al. (1987) studied this question. Ryanodine and rest duration vs. Untreated muscles was evaluated on Cumulative depletions of extracellular Ca. Ryanodine enhanced cumulative depletions of extracellular calcium after short rest intervals and increased the rate of calcium loss from rabbit ventricular muscle cells upon cessation of stimulation.