Key result
Beta thalassemia patients had significantly lower systolic strain in the lateral LV wall compared to normal controls (20.9 vs 27.2, p<0.001), indicating early regional systolic dysfunction.
Why the study?
Do tissue velocity and strain imaging detect early regional myocardial dysfunction in patients with beta thalassemia compared to normal subjects?
Population
41 subjects, comprising 27 patients with beta thalassemia and 14 age-matched normal subjects
Comparison
Tissue velocity imaging and strain imaging vs Normal subjects (healthy controls)
Design
Case-control
Authors
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Strain imaging may detect early regional LV dysfunction in beta thalassemia; hypothesis-generating and requires prospective validation before clinical use.
Case-Control (n=41)
Do tissue velocity and strain imaging detect early regional myocardial dysfunction in patients with beta thalassemia compared to normal subjects?
Absolute Event Rate: 20.9% vs 27.2%
p-value: p=<0.001
Tissue velocity and strain imaging are promising tools for the early quantitative detection of regional systolic and diastolic myocardial dysfunction in patients with beta thalassemia.
Amal M. Hamdy (2006) conducted a case-control in beta thalassemia (n=41). Beta thalassemia vs. Normal subjects was evaluated on Systolic strain in the lateral LV wall (S-LV) (p=<0.001). Beta thalassemia patients had significantly lower systolic strain in the lateral LV wall compared to normal controls (20.9 vs 27.2, p<0.001), indicating early regional systolic dysfunction.
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